Urticaria

Overview

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Urticaria, commonly known as hives, is a skin condition characterized by raised, itchy welts or rashes. These welts can vary in size and may appear and disappear quickly. Urticaria can be acute (lasting less than six weeks) or chronic (lasting more than six weeks). It results from an allergic reaction or other triggers causing the release of histamine in the skin.

These welts can vary in size and may appear and disappear quickly. Urticaria can be acute (lasting less than six weeks) or chronic (lasting more than six weeks). It results from an allergic reaction or other triggers causing the release of histamine in the skin.

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Symptoms
  • Raised Welts: Red or skin-colored bumps that can vary in size and shape.
  • Itching: Often intense, leading to scratching and discomfort.
  • Swelling: Can affect larger areas of the skin, particularly on the face, lips, or eyes (angioedema).
  • Flushing: Redness of the skin may occur.
Complications
  • Anaphylaxis: In severe cases, urticaria can be associated with anaphylactic reactions, leading to difficulty breathing and swelling of the throat.
  • Chronic Symptoms: Chronic urticaria can impact quality of life due to persistent itching and discomfort.
  • Skin Infections: Frequent scratching may lead to skin infections.
Causes

Urticaria Can be Triggered by Various Factors, Including

  • Allergic Reactions: Foods, medications, insect stings, and latex.
  • Environmental Factors: Heat, cold, sunlight, or pressure.
  • Infections: Viral infections are common triggers, particularly in children.
  • Autoimmune Disorders: Conditions where the immune system attacks the body.
  • Stress: Emotional stress can also be a contributing factor.
Prevention

While not All Cases of Urticaria Can be Prevented, Certain Measures Can Help Reduce the Risk

  • Avoid Known Triggers: Identifying and avoiding specific allergens or irritants.
  • Manage Stress: Employing stress-reduction techniques such as mindfulness or relaxation exercises.
  • Follow a Healthy Lifestyle: Eating a balanced diet and maintaining good overall health can support immune function.
Risk Factors
  • History of Allergies: Individuals with a history of allergies are more likely to develop urticaria.
  • Family History: Genetic predisposition may play a role.
  • Age: Acute urticaria is more common in children, while chronic urticaria can occur at any age.
  • Other Health Conditions: People with autoimmune diseases or chronic infections may be at increased risk.
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How is it treated?

  • Antihistamines: First-line treatment to reduce itching and swelling.
  • Corticosteroids: Short-term use may be prescribed for severe cases or acute exacerbations.
  • Omalizumab: A medication for chronic urticaria that is resistant to standard treatments.
  • Avoidance of Triggers: Identifying and avoiding known allergens or irritants.
  • Emergency Care: In cases of severe allergic reactions or anaphylaxis, immediate medical attention is necessary.
  • If you experience symptoms of urticaria, especially if they are persistent or severe, consult a healthcare provider for diagnosis and management. Early intervention can help alleviate symptoms and prevent complications.
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How is it Diagnosed?

Urticaria, or hives, is primarily diagnosed clinically based on a detailed patient history and physical examination. The condition is characterized by the sudden appearance of red, raised, itchy welts on the skin that typically resolve within 24 hours. Diagnosis includes identifying the pattern (acute or chronic), possible triggers (foods, medications, infections, stress, temperature), and associated symptoms like angioedema.

There are no specific tests for urticaria itself, but routine blood tests (CBC, ESR, CRP) may help rule out underlying infections or autoimmune disorders. In chronic or recurrent cases, thyroid function tests, ANA, or specific IgE tests may be ordered. Skin prick testing or serum-specific IgE may identify allergens in suspected allergic urticaria.

In physical urticarias (e.g., cold, pressure, cholinergic), provocation tests (ice cube test, exercise challenge) are performed. Chronic spontaneous urticaria often has no identifiable cause and is diagnosed after ruling out differential diagnoses like vasculitis, which requires a skin biopsy.

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