Endometriosis

Overview

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Endometriosis is a chronic medical condition where tissue similar to the lining of the uterus (endometrium) grows outside the uterus. This tissue can develop on the ovaries, fallopian tubes, the outer surface of the uterus, and other organs in the pelvis. It can lead to pain, irregular bleeding, and potential fertility issues. The exact cause of endometriosis remains unclear, but it is a common condition affecting about 10% of women of reproductive age.

It can lead to pain, irregular bleeding, and potential fertility issues. The exact cause of endometriosis remains unclear, but it is a common condition affecting about 10% of women of reproductive age.

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Symptoms
  • Pelvic Pain: Often linked to the menstrual cycle but can occur at other times.
  • Menstrual Irregularities: Heavy periods (menorrhagia) or bleeding between periods.
  • Pain During Intercourse: Discomfort during or after sex.
  • Pain with Bowel Movements or Urination: Typically observed during menstruation.
  • Infertility: Endometriosis can be a factor in infertility, affecting 20-40% of women who are unable to conceive.
  • Other Symptoms: Fatigue, diarrhea, constipation, nausea, and lower back pain.
Complications
  • Infertility: Endometriosis can cause scarring and adhesions that may impact fertility.
  • Ovarian Cysts: Endometriomas, or “chocolate cysts,” can form on the ovaries.
  • Adhesions: Scar tissue may cause organs to stick together.
  • Increased Risk of Certain Cancers: A slightly higher risk of ovarian cancer has been noted, although this is rare.
Causes

The exact cause of endometriosis is not fully known, but several theories include

  • Retrograde Menstruation: Menstrual blood flows backward through the fallopian tubes into the pelvic cavity.
  • Embryonic Cell Transformation: Hormones like estrogen might transform embryonic cells into endometrial-like cells.
  • Immune System Disorders: Abnormal immune responses may prevent the body from recognizing endometrial-like tissue outside the uterus.
  • Genetics: A family history of endometriosis may increase the risk, suggesting a genetic component.
Prevention

While there is no guaranteed way to prevent endometriosis, some strategies might help reduce the risk or manage symptoms

  • Regular Exercise: Can help with hormone regulation and reduce menstrual pain.
  • Healthy Diet: Anti-inflammatory foods may alleviate symptoms.
  • Pregnancy: Some studies suggest that pregnancy might lower the risk.
  • Menstrual Management: Hormonal contraceptives can help regulate menstruation and potentially reduce endometrial growth.
Risk Factors
  • Family History: Having a close relative with endometriosis increases the risk.
  • Menstrual History: Early onset of menstruation or short menstrual cycles may be associated.
  • Never Giving Birth: Women who have never been pregnant might have a higher risk.
  • Low Body Mass Index (BMI): Some research suggests a potential link.
  • Short Menstrual Cycles: Menstrual cycles lasting less than 27 days might be a risk factor.
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How is it treated?

Treatment focuses on pain relief, symptom management, and improving quality of life

  • Pain Relief: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.
  • Hormonal Therapy: Options include birth control pills, progestin therapy, or GnRH agonists to reduce or eliminate menstruation.
  • Surgery: For severe cases, laparoscopic surgery to remove endometrial tissue. In some cases, hysterectomy (removal of the uterus) combined with ovarian removal may be considered.
  • Lifestyle and Home Remedies: Heat application, dietary changes, physical therapy, and stress management techniques.
  • Management of endometriosis is individualized, and ongoing follow-up with a healthcare provider is crucial for effective treatment and symptom control.
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How is it Diagnosed?

Endometriosis is diagnosed primarily through clinical assessment and, when needed, surgical visualization. It occurs when endometrial-like tissue grows outside the uterus, often causing chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility.

The diagnostic process begins with a detailed history and physical examination. Pelvic examination may reveal tenderness, nodularity in the posterior fornix, or fixed uterus in advanced cases. Imaging plays a supporting role: transvaginal ultrasound is useful, particularly for detecting endometriomas (ovarian cysts caused by endometriosis). However, it may miss superficial peritoneal lesions.

MRI is more sensitive for detecting deep infiltrating endometriosis affecting bowel, bladder, or uterosacral ligaments. Nonetheless, the definitive diagnosis is made via laparoscopy, a minimally invasive surgery that allows direct visualization and biopsy of endometriotic lesions. Histopathological confirmation is considered the gold standard.

There is often a significant delay in diagnosis—averaging several years—due to overlapping symptoms with other pelvic disorders. Hence, some patients may be offered empirical treatment based on clinical suspicion alone, especially when imaging is inconclusive but symptoms are typical.

Early diagnosis enables better symptom control, fertility preservation, and improved quality of life through medical therapy (like hormonal suppression) or surgical excision.

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