Depression

Overview

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Depression, also known as major depressive disorder (MDD), is a common and serious mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities. It affects a person’s ability to function in daily life and can have a profound impact on emotional, physical, and social well-being. Depression can occur at any age and may vary in severity.

It affects a person’s ability to function in daily life and can have a profound impact on emotional, physical, and social well-being. Depression can occur at any age and may vary in severity.

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Symptoms

Symptoms of depression can vary but generally include:

Emotional Symptoms:

  • Persistent sadness or low mood.
  • Feelings of hopelessness or worthlessness.
  • Irritability or excessive anger.
  • Guilt or self-blame.

Behavioral Symptoms:

  • Loss of interest or pleasure in previously enjoyed activities (anhedonia).
  • Withdrawal from social activities and relationships.
  • Difficulty performing daily tasks or maintaining responsibilities.

Cognitive Symptoms:

  • Difficulty concentrating, making decisions, or remembering things.
  • Pessimistic or negative thinking patterns.

Physical Symptoms:

  • Changes in appetite or weight (increase or decrease).
  • Sleep disturbances (insomnia or excessive sleeping).
  • Fatigue or decreased energy.
  • Unexplained physical symptoms, such as aches and pains.

Severe Symptoms:

  • Thoughts of death or suicide.
  • Suicide attempts or self-harm behaviors.
Complications

Depression can lead to a range of complications, including:

  • Increased Risk of Suicide: Severe depression can lead to suicidal thoughts or behaviors.
  • Chronic Health Conditions: Depression is linked with a higher risk of developing chronic physical conditions such as heart disease, diabetes, or obesity.
  • Substance Abuse: Increased risk of alcohol or drug misuse as individuals may use substances to cope with symptoms.
  • Impaired Functioning: Difficulties in work, school, and social relationships, leading to reduced quality of life.
  • Self-Neglect: Poor self-care and neglect of personal hygiene and health.
Causes

The exact causes of depression are not fully understood, but several factors contribute:

  • Genetic Factors: A family history of depression or other mental health disorders can increase the risk.
  • Biological Factors: Neurotransmitter imbalances (e.g., serotonin, norepinephrine) and hormonal changes can play a role.
  • Psychological Factors: Negative thinking patterns, low self-esteem, and stressful life events.
  • Environmental Factors: Trauma, abuse, chronic stress, or significant life changes (e.g., job loss, divorce).
  • Medical Conditions: Chronic illnesses or neurological conditions can contribute to depressive symptoms.
Prevention

While it may not be possible to completely prevent depression, certain strategies can reduce the risk or help manage symptoms:

  • Healthy Lifestyle: Regular exercise, a balanced diet, and adequate sleep.
  • Stress Management: Techniques such as mindfulness, meditation, and relaxation exercises.
  • Social Support: Building and maintaining strong social connections and seeking support from friends and family.
  • Professional Help: Seeking therapy or counseling, especially if experiencing symptoms of depression.
  • Education: Increasing awareness about depression and mental health to reduce stigma and encourage early intervention.
Risk Factors

Risk factors for depression include:

  • Family History: A genetic predisposition to mood disorders.
  • Gender: Women are more likely to experience depression than men, though men can also be affected.
  • Age: Depression can occur at any age but may present differently across the lifespan.
  • Previous Episodes: A history of depression increases the risk of recurrence.
  • Chronic Stress or Trauma: Exposure to stressful life events or traumatic experiences.
  • Medical Conditions: Chronic illnesses, neurological disorders, or significant physical health problems.
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How is it treated?

Treatment for depression typically involves a combination of therapies:

Medication:

  • Antidepressants: Such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others. These can help balance neurotransmitters in the brain.
  • Other Medications: May be prescribed based on individual needs, including mood stabilizers or antipsychotic medications in some cases.

Psychotherapy:

  • Cognitive Behavioral Therapy (CBT): Focuses on changing negative thinking patterns and behaviors.
  • Interpersonal Therapy (IPT): Addresses interpersonal issues and relationships that may contribute to depression.
  • Other Therapies: Such as psychodynamic therapy, acceptance and commitment therapy (ACT), or dialectical behavior therapy (DBT).

Lifestyle Changes:

  • Exercise: Regular physical activity can improve mood and overall well-being.
  • Healthy Eating: A nutritious diet supports overall health and may influence mood.

Support Services:

  • Support Groups: Connecting with others who have similar experiences.
  • Case Management: Assistance with navigating resources and services.

In Severe Cases:

  • Electroconvulsive Therapy (ECT): For treatment-resistant depression or severe cases, ECT may be considered.
  • Hospitalization: May be necessary for safety or intensive treatment if there are severe symptoms or risks of self-harm.
  • Effective treatment often involves a combination of medication, therapy, and lifestyle adjustments, tailored to the individual’s needs. Regular follow-up with mental health professionals is crucial for managing depression and improving overall quality of life.
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How is it Diagnosed?

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  • Chemotherapy.
  • Targeted therapy with gilteritinib
  • Enasidenib
  • Ivosidenib
  • Maintenance therapy with chemotherapy.
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