Trans-Bronchial Biopsy (TBB)

Overview

A Trans-Bronchial Biopsy (TBB) is a minimally invasive diagnostic procedure used to obtain tissue samples from the lungs. It is performed via bronchoscopy, which involves inserting a thin, flexible tube (bronchoscope) into the airways. The procedure is primarily used to diagnose lung diseases, infections, inflammatory conditions, or cancers by analyzing lung tissue samples.

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How is Trans-Bronchial Biopsy (TBB) done?

Medical History and Physical Exam:
  • The doctor will evaluate the patient's medical history and perform a physical exam. They will check for any existing lung conditions, medications (especially blood thinners), or allergies.
Pre-Procedure Tests:
  • Chest X-ray or CT Scan: Often performed before the biopsy to guide the procedure.
  • Pulmonary Function Tests (PFTs): To assess lung function.
  • Blood Tests: Coagulation profile to ensure there is no excessive bleeding risk.
  • Fasting: The patient may need to fast for 6-8 hours before the procedure.
  • Consent: The procedure risks and benefits will be explained, and informed consent will be obtained.
  • Medications: Adjustments may be made to certain medications, such as stopping anticoagulants (blood thinners).

  • Sedation/Anesthesia: TBB is usually performed under local anesthesia with sedation, but general anesthesia may be used in some cases.
  • Positioning The patient lies on their back or side during the procedure.
  • Bronchoscope Insertion: The bronchoscope is inserted through the mouth or nose, passing down the trachea and into the bronchi (airways leading to the lungs).
  • Sample Collection: The physician inserts biopsy forceps through the bronchoscope to take small tissue samples from the lung. Fluoroscopy (real-time X-ray) or endobronchial ultrasound (EBUS) may be used to guide the process.
  • Completion: After collecting tissue samples, the bronchoscope is removed, and the patient is monitored while the sedation wears off.
  • Post-Procedure: The patient is usually observed for a few hours to monitor for any complications. In most cases, the patient can go home the same day.

While TBB is generally safe, complications can occur:
  • Bleeding: The most common complication; usually mild but occasionally severe.
  • Pneumothorax: Air leakage into the pleural space (between the lungs and chest wall), causing a collapsed lung. Rare but serious.
  • Infection: Risk of lung infection after the procedure.
  • Respiratory Distress: Difficulty breathing may occur, especially in patients with pre-existing lung conditions.
  • Bronchospasm: Narrowing of the airways leading to breathing difficulties.
What are the benefits Trans-Bronchial Biopsy (TBB)?
  • Accurate Diagnosis: TBB allows for precise diagnosis of lung diseases, including infections, interstitial lung diseases, and cancer.
  • Minimally Invasive: Unlike open surgical biopsies, TBB is less invasive with a quicker recovery time.
  • Guided Precision: Fluoroscopy or ultrasound guidance improves the accuracy of tissue sampling.

Infrastructure & Facilities

  • Bronchoscopy Suite: Equipped with bronchoscopy instruments, biopsy forceps, and real-time imaging (fluoroscopy/EBUS).
  • Sterile Environment: To prevent infection.
  • Monitoring Equipment: Oxygen supply, pulse oximetry, ECG, and blood pressure monitors.
  • Emergency Care: Facility for treating potential complications like pneumothorax or bleeding.
  • Trained Staff: Including a pulmonologist, anesthesiologist, and nursing staff.

FAQs

The procedure is generally not painful because sedation or anesthesia is used. Some patients may experience mild discomfort during recovery.

The procedure itself usually takes 30-60 minutes, but you may spend a few hours in the hospital for preparation and observation.

Severe shortness of breath, persistent coughing up blood, chest pain, or fever after the procedure should be reported to a doctor immediately.

Most patients can resume normal activities within 24 hours, but strenuous activities and smoking should be avoided for a few days.

Biopsy results are usually available within a few days to a week, depending on the type of tests performed on the tissue samples.

If the biopsy is inconclusive, further tests or another type of biopsy (such as a surgical biopsy) may be recommended.

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